Our lab’s most recent work, entitled “Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence” was published in Nature Communications. Mariya Goncheva et al. teamed up to investigate the effect of mutations in the purine biosynthesis repressor on the pathogenic potential of S. aureus.
Ron Flannagan's paper, entitled "A fluorescence based-proliferation assay for the identification of replicating bacteria within host cells," describes a powerful assay routinely used in our lab for the investigation of bacterial replication at the subcellular level.
Julie Kaiser’s most recent work describes the role of branched-chain amino acids in bacterial adaptation to nutrient starvation. The paper is entitled “Branching Out: Alterations in Bacterial Physiology and Virulence Due to Branched-Chain Amino Acid Deprivation”.
Ron Flannagan's most recent work on the interaction of S. aureus with macrophages was published in mBio. Thanks to contributions from Robert Kuiack in Martin McGavin's lab on the study. The paper is entitled "Staphylococcus aureus uses the GraXRS regulatory system to sense and adapt to the acidified phagolysosome in macrophages"